A drama critic learns on his wedding day that his beloved maiden aunts are homicidal maniacs, and that insanity runs in his family.
| Actor | Role |
|---|---|
 Helen HayesAbby Brewster | Abby Brewster |
 Bob CraneMortimer Brewster | Mortimer Brewster |
 Lillian GishMartha Brewster | Martha Brewster |
 Fred GwynneJonathan Brewster | Jonathan Brewster |
 Sue LyonElaine Harper | Elaine Harper |
 Bob DishyCop | Cop |
 Jack GilfordDr. Jonas Salk | Dr. Jonas Salk |
 David WayneTeddy Brewster | Teddy Brewster |
 Billy De WolfeOfficer O'Hara | Officer O'Hara |
 Richard DeaconMr. Witherspoon | Mr. Witherspoon |
 Frank CampanellaNot listed | Not listed |
 Victor KilianNot listed | Not listed |
| BBill SmillieNot listed | Not listed |