 Dana SnyderMaster Shake (voice) | Master Shake (voice) |
 Carey MeansFrylock (voice) | Frylock (voice) |
 Dave WillisMeatwad / Carl / Ignignokt / Video Game Voice (voice) | Meatwad / Carl / Ignignokt / Video Game Voice (voice) |
| AAndy MerrillOglethorpe (voice) | Oglethorpe (voice) |
 Bruce CampbellChicken Bittle (voice) | Chicken Bittle (voice) |
 Fred ArmisenTime Lincoln (voice) | Time Lincoln (voice) |
 Chris KattanWalter Melon (voice) | Walter Melon (voice) |
 Matt MaiellaroErr / Cybernetic Ghost / Satan (voice) | Err / Cybernetic Ghost / Satan (voice) |
| MMike SchatzEmory (voice) | Emory (voice) |
 C. Martin CrokerDr. Weird / Steve (voice) | Dr. Weird / Steve (voice) |
 Neil PeartNeil Peart of Rush (voice) | Neil Peart of Rush (voice) |
| MMC ChrisMC Pee Pants (voice) | MC Pee Pants (voice) |
 George LoweSpace Ghost (voice) | Space Ghost (voice) |
 Isaac Hayes IIIPlantation Owner (voice) | Plantation Owner (voice) |
 Tina FeyNine-Layer Bean Burrito (voice) | Nine-Layer Bean Burrito (voice) |
 H. Jon BenjaminCIA Agent 1 (voice) | CIA Agent 1 (voice) |
 Jon GlaserCIA Agent 2 (voice) | CIA Agent 2 (voice) |
| CCraig HartinRob Goldstein (voice) | Rob Goldstein (voice) |
| MMatt HarriganLinda (voice) | Linda (voice) |
| MMastodonInterrupting Snack Band (uncredited) | Interrupting Snack Band (uncredited) |
