Anne Shirley, an orphan, is fostered by farmer Matthew Cuthbert and his sister Marilla, who were expecting a boy to be sent them to help with their farm work. They accept Anne, who quickly endears herself to them and to the local villagers.
| Actor | Role |
|---|---|
 Anne ShirleyAnne Shirley | Anne Shirley |
 O. P. HeggieMatthew Cuthbert | Matthew Cuthbert |
 Helen WestleyMarilla Cuthbert | Marilla Cuthbert |
 Tom BrownGilbert Blythe | Gilbert Blythe |
 Sara HadenMrs. Barry | Mrs. Barry |
 Murray KinnellMr. Phillips | Mr. Phillips |
 Gertrude MessingerDiana | Diana |
 Charley GrapewinDr. Tatum | Dr. Tatum |
 Hilda VaughnMrs. Blewett | Mrs. Blewett |
| JJune PrestonThe Little Blewett Girl | The Little Blewett Girl |
 Frank DarienAngus the Station Master (uncredited) | Angus the Station Master (uncredited) |
 George Offerman, Jr.Herbert Root (uncredited) | Herbert Root (uncredited) |
 Paul StantonDr. Terry (uncredited) | Dr. Terry (uncredited) |