 Irene DunneAnn Vickers | Ann Vickers |
 Walter HustonBarney Dolphin | Barney Dolphin |
 Conrad NagelLindsey Atwell | Lindsey Atwell |
 Bruce CabotCaptain Lafe Resnick | Captain Lafe Resnick |
 Edna May OliverMalvina Wormser | Malvina Wormser |
 Sam HardyRussell Spaulding | Russell Spaulding |
 Mitchell LewisCaptain Waldo | Captain Waldo |
 Murray KinnellDr. Slenk - Copper Gap Warden | Dr. Slenk - Copper Gap Warden |
 Helen Eby-RockKitty Cognac | Kitty Cognac |
 Gertrude MichaelMona Dolphin | Mona Dolphin |
 J. Carrol NaishDr. Sorelle | Dr. Sorelle |
 Sarah PaddenLil | Lil |
 Reginald BarlowChaplain | Chaplain |
 Rafaela OttianoMrs. Feldermans | Mrs. Feldermans |
 Wally AlbrightMischa Feldermans (uncredited) | Mischa Feldermans (uncredited) |
 Margaret ArmstrongMiss Jones (uncredited) | Miss Jones (uncredited) |
 Irving BaconWaiter (uncredited) | Waiter (uncredited) |
 May BeattyNurse (uncredited) | Nurse (uncredited) |
| KKatherine BlockPrison Matron (uncredited) | Prison Matron (uncredited) |
 Estelle BrodyPrisoner (uncredited) | Prisoner (uncredited) |
 William P. CarletonBit Part (uncredited) | Bit Part (uncredited) |
| JJimmy CaseyReporter (uncredited) | Reporter (uncredited) |
 Bill CodyGuard (uncredited) | Guard (uncredited) |
| HHelen CromwellMrs. Bingham (uncredited) | Mrs. Bingham (uncredited) |
 John CromwellSad Faced Doughboy (uncredited) | Sad Faced Doughboy (uncredited) |
| JJenny DarkPrisoner (uncredited) | Prisoner (uncredited) |
 Jane DarwellMrs. Gage (uncredited) | Mrs. Gage (uncredited) |
| RRobert DoranBit Part (uncredited) | Bit Part (uncredited) |
 Mary FoyBig Prison Matron in Warden's Office (uncredited) | Big Prison Matron in Warden's Office (uncredited) |
 Jack GarganBit Part (uncredited) | Bit Part (uncredited) |
