 Rob PaulsenYakko Warner / Pinky / Dr. Otto Scratchansniff (voice) | Yakko Warner / Pinky / Dr. Otto Scratchansniff (voice) |
 Jess HarnellWakko Warner (voice) | Wakko Warner (voice) |
 Tress MacNeilleDot Warner / Marita Hippo / Hello Nurse / Mindy's Mother (voice) | Dot Warner / Marita Hippo / Hello Nurse / Mindy's Mother (voice) |
 Maurice LaMarcheBrain / Squit (voice) | Brain / Squit (voice) |
 Nancy CartwrightMindy (voice) | Mindy (voice) |
 Frank WelkerVarious (voice) | Various (voice) |
 Chick VenneraPesto (voice) | Pesto (voice) |
 John MarianoBobby / Gas Station Attendant (voice) | Bobby / Gas Station Attendant (voice) |
 Bernadette PetersRita (voice) | Rita (voice) |
 Sherri StonerSlappy Squirrel (voice) | Slappy Squirrel (voice) |
 Paxton WhiteheadKing Salazar (voice) | King Salazar (voice) |
 Ben SteinDesire Fulfillment Facilitator (voice) | Desire Fulfillment Facilitator (voice) |
 Jeff BennettCaptain of the Guard / Baloney (voice) | Captain of the Guard / Baloney (voice) |
 Paul RuggMr. Director (voice) | Mr. Director (voice) |
 Julie BrownMinerva Mink (voice) | Minerva Mink (voice) |
 Tom BodettNarrator (voice) | Narrator (voice) |
 Julie BernsteinSinger (voice) | Singer (voice) |
| SSteven BernsteinSinger (voice) | Singer (voice) |
 Bobbi PageSinger (voice) | Singer (voice) |
| NNathan RueggerSkippy Squirrel (voice) | Skippy Squirrel (voice) |
