After struggling and finally conceiving a child, Roxy and Vinnie Ventola, a successful television writing couple, learns that their newborn has AIDS. Soon afterward, the two parents are also diagnosed with the fatal virus.
| Actor | Role |
|---|---|
 Amy MadiganRoxy Ventola | Roxy Ventola |
 Dennis BoutsikarisVinnie Ventola | Vinnie Ventola |
 Jane DalyLorrie | Lorrie |
 Steven FlynnJack | Jack |
 Jennifer HetrickJanet | Janet |
| JJohn RobinsonWilkes | Wilkes |
 Martha HenryDr. Moore | Dr. Moore |
 Cameron ArnettLenny | Lenny |
 Kenneth WelshDavid Burns | David Burns |
 Richard MonetteDr. Lloyd | Dr. Lloyd |
 Dawn GreenhalghJulia Sands | Julia Sands |
 Henry RamerRoxy's dad | Roxy's dad |
 Pam HyattRoxy's mom | Roxy's mom |
 Damir AndreiDr. Goodman | Dr. Goodman |
| GGabe CohenDr. Benner | Dr. Benner |
 Tabitha St. GermainICU Nurse (as Paulina Gillis) | ICU Nurse (as Paulina Gillis) |
| NNaz EdwardsMaternity Nurse | Maternity Nurse |
| KKenner AmesWriter | Writer |
 Nigel HamerIntern | Intern |
| BBeatriz PizanoECMO Nurse | ECMO Nurse |
 Will CornoWaiter | Waiter |
 Nancy Anne SakovichLena Burns | Lena Burns |
 Corey SevierGrim Reaper | Grim Reaper |
| KKarlie BrownMiranda at 2 years | Miranda at 2 years |
| KKirstie BrownMiranda at 2 years | Miranda at 2 years |