A middle-aged couple with three grown children discovers that they soon will be parents once more and faces a variety of emotional responses from friends and family.
| Actor | Role |
|---|---|
 Colleen DewhurstAnna Kramer | Anna Kramer |
 Warren OatesMichael Kramer | Michael Kramer |
 Maggie CooperElizabeth Kramer Winston | Elizabeth Kramer Winston |
 Al CorleyFranklin Kramer | Franklin Kramer |
 Timothy HuttonJason Kramer | Jason Kramer |
 Allyn Ann McLerieDora Finley | Dora Finley |
 Mildred DunnockSerena Fox | Serena Fox |
 Mason AdamsDr. Eliot Losen | Dr. Eliot Losen |
 Maria MelendezMarta Montez | Marta Montez |
| BBill SmilliePharmacist | Pharmacist |
 Lee WallaceSam Blumenkrantz | Sam Blumenkrantz |
 Christopher AllportJeff Winston | Jeff Winston |
 Tamu BlackwellDonna | Donna |
| JJosh GrenrockAlex | Alex |
| RRichard RoatBill Finley | Bill Finley |
| RRuth SilveiraNurse #2 | Nurse #2 |
 Renny RokerMailman | Mailman |
| CConstance PfeiferNurse #1 | Nurse #1 |
| NNora BolandOlder Patient | Older Patient |
| EEdith FieldsSchool Nurse | School Nurse |
| HHelen LockwoodReceptionist | Receptionist |