The show will celebrate not only their sketch characters, but also, for the first time, will introduce the real Harry and Paul, who appear almost live on stage as themselves as they take questions and introduce their favourite sketches from programmes including Harry Enfield and Chums, Harry and Paul and Harry Enfield's Television Programme. These include Kevin Patterson, Tim Nice-But-Dim, Wayne and Waynetta Slob, Dragons' Den, The Scousers and Smashie and Nicey. Harry and Paul also take it in turns to play the host of celebrities that have joined them to celebrate their anniversary, such as Mark Rylance as Thomas Cromwell from BBC Drama Wolf Hall; Rob Brydon, Ricky Gervais, Prince Charles, Miranda Hart, Stephen Hawking, Boris Johnson, Melyn Bragg and Jimmy Carr as they take viewers on a trip down memory lane. There's also a very special guest appearance from a Harry and Paul favourite.
| Actor | Role |
|---|---|
 Harry EnfieldNot listed | Not listed |
 Paul WhitehouseNot listed | Not listed |
 Kathy BurkeNot listed | Not listed |
 Rosie CavalieroMel | Mel |