Charlie, Itchy and Sasha itch and scratch their way through everything and anything in an effort to save Christmas from the wicked hellhound Belladonna, who wants to use dogs from all over the world to ruin Christmas.
| Actor | Role |
|---|---|
 Steven WeberCharlie B. Barkin (voice) | Charlie B. Barkin (voice) |
 Dom DeLuiseItchy Itchiford (voice) | Itchy Itchiford (voice) |
 Bebe NeuwirthAnabelle / Belladonna (voice) | Anabelle / Belladonna (voice) |
 Sheena EastonSasha La Fleur (voice) | Sasha La Fleur (voice) |
 Ernest BorgnineCarface Carruthers (voice) | Carface Carruthers (voice) |
 Charles Nelson ReillyKiller (voice) | Killer (voice) |
| BBeth AndersenMartha (voice) | Martha (voice) |
 Taylor EmersonTimmy (voice) | Timmy (voice) |
 Myles JeffreyScruffy (voice) | Scruffy (voice) |
 Aria Noelle CurzonFemale Puppy Angel (voice) | Female Puppy Angel (voice) |
 Ashley FrenchFemale Puppy (voice) | Female Puppy (voice) |
| LLaurie A. SchillingerAdditional Voices (voice) | Additional Voices (voice) |