The ultimate battle against the Amityville curse begins after the infamous murder house is exorcised from Earth and reappears in outer space in Amityville in Space.
| Actor | Role |
|---|---|
 Titus HimmelbergerCaptain Halstead | Captain Halstead |
| CCassandra HayesDr. Nurmi | Dr. Nurmi |
 Jeff KirkendallFather Benna | Father Benna |
| TTim HatchMaitland | Maitland |
| RRyan DaltonJacowitz | Jacowitz |
| NNatalie HimmelbergerTyse | Tyse |
| MMichael KorotitschVox | Vox |
| YYolie CanalesNews reporter | News reporter |
| CChristopher BeacomCameraman | Cameraman |
 Mark PoloniaRescue Team Member | Rescue Team Member |