 Danny GloverSilas (segment "Long Black Song") | Silas (segment "Long Black Song") |
 Wesley SnipesGeorge Du Vaul (segment "The Boy Who Painted Christ Black") | George Du Vaul (segment "The Boy Who Painted Christ Black") |
 Lorraine ToussaintPhilomena (segment "The Reunion") | Philomena (segment "The Reunion") |
 Tate DonovanDavid (segment "Long Black Song") | David (segment "Long Black Song") |
 Norman D. Golden IIAaron (segment "The Boy Who Painted Christ Black") | Aaron (segment "The Boy Who Painted Christ Black") |
 Susanna ThompsonBeth Ann (segment "The Boy Who Painted Christ Black") | Beth Ann (segment "The Boy Who Painted Christ Black") |
 Jasmine GuyElna Du Vaul (segment "The Boy Who Painted Christ Black") | Elna Du Vaul (segment "The Boy Who Painted Christ Black") |
 Tina LiffordSarah (segment "Long Black Song") | Sarah (segment "Long Black Song") |
 Carl LumblyCal (segment "The Boy Who Painted Christ Black") | Cal (segment "The Boy Who Painted Christ Black") |
 Bennet GuilloryWillie (segment "The Boy Who Painted Christ Black") | Willie (segment "The Boy Who Painted Christ Black") |
 Danny KaminMr. Harper (segment "Long Black Song") | Mr. Harper (segment "Long Black Song") |
| RRae'Ven Larrymore KellyLara (segment "The Boy Who Painted Christ Black") | Lara (segment "The Boy Who Painted Christ Black") |
 Timothy CarhartProf. Daniel (segment "The Boy Who Painted Christ Black") | Prof. Daniel (segment "The Boy Who Painted Christ Black") |
| SSummer Ross JeffersonYoung Philomena #1 (segment "The Boy Who Painted Christ Black") | Young Philomena #1 (segment "The Boy Who Painted Christ Black") |
 Vanessa Bell CallowayMiss Williams (segment "The Boy Who Painted Christ Black") | Miss Williams (segment "The Boy Who Painted Christ Black") |
| WWinter Elaine JeffersonYoung Philomena #2 (segment "The Boy Who Painted Christ Black") | Young Philomena #2 (segment "The Boy Who Painted Christ Black") |
| AAmanda AddisonYoung Beth Ann (segment "The Boy Who Painted Christ Black") | Young Beth Ann (segment "The Boy Who Painted Christ Black") |
 Kevin Jamal WoodsClyde (segment "The Boy Who Painted Christ Black") | Clyde (segment "The Boy Who Painted Christ Black") |
| RRuth BeckfordMrs. McClaren (segment "The Boy Who Painted Christ Black") | Mrs. McClaren (segment "The Boy Who Painted Christ Black") |
 Yolanda KingMrs. Crawford (segment "The Boy Who Painted Christ Black") | Mrs. Crawford (segment "The Boy Who Painted Christ Black") |
| DDouglas CunninghamDrummer (uncredited) | Drummer (uncredited) |
 Tammy ThomasWaitress (uncredited) | Waitress (uncredited) |