Sidesplitters stars Lewis Black (the Daily Show, and the owner of the club in American Dummy) and Jim Norton (the clubs Host in American Dummy) as a comedy team in vein of Abbot and Costello or the Marx Brothers. It follows their career together from the Vaudville stage to the retirement home.
| Actor | Role |
|---|---|
| OOtto PetersenJerry / Dino / Fritz | Jerry / Dino / Fritz |
 Jim BreuerTony Metropolis | Tony Metropolis |
 Lewis BlackClub Owner | Club Owner |
 Jim NortonEddie Barnum | Eddie Barnum |
| PPete CorrealeSal Salvino | Sal Salvino |
 Greg GiraldoDr. Mabuse | Dr. Mabuse |
 Nina HartleySherry Weitz | Sherry Weitz |
| VVanessa HollingsheadVanessa Hollingshead | Vanessa Hollingshead |