 Jason LeeDave | Dave |
 David CrossIan | Ian |
 Jenny SlateZoe | Zoe |
 Justin LongAlvin (voice) | Alvin (voice) |
 Matthew Gray GublerSimon (voice) | Simon (voice) |
 Jesse McCartneyTheodore (voice) | Theodore (voice) |
 Amy PoehlerEleanor (voice) | Eleanor (voice) |
 Anna FarisJeanette (voice) | Jeanette (voice) |
 Christina ApplegateBrittany (voice) | Brittany (voice) |
 Alan TudykSimone (voice) | Simone (voice) |
 Michael P. NortheyHawaiian Shirt Guy | Hawaiian Shirt Guy |
| SSophia AguiarClub Woman #1 | Club Woman #1 |
 Lauren GottliebClub Woman #2 | Club Woman #2 |
| TTera PerezClub Woman #3 | Club Woman #3 |
 Andy BuckleyCaptain Correlli | Captain Correlli |
 Chad KrowchukWaiter | Waiter |
 Luisa d'OliveiraTessa | Tessa |
 Tucker AlbrizziTucker / Kite Kid | Tucker / Kite Kid |
 Nelson WongCasino Guy | Casino Guy |
| MMichael BagdasarianExcursion Clerk | Excursion Clerk |
| AAmber-Rochelle DeMarcoDamsel #1 | Damsel #1 |
| MMarcela CaceresDamsel #2 | Damsel #2 |
| NNatalie SutcliffeDamsel #3 | Damsel #3 |
 Ian HarmonMonster | Monster |
 Phyllis SmithFlight Attendant | Flight Attendant |
 Ross Bagdasarian Jr.Alvin (singing voice) (uncredited) | Alvin (singing voice) (uncredited) |
 Janice KarmanTheodore / The Chipettes (singing voice) (uncredited) | Theodore / The Chipettes (singing voice) (uncredited) |
| EEoin BatesMusic Executive (uncredited) | Music Executive (uncredited) |
| SSeth Robert DuskyAdditional Voices (voice) (uncredited) | Additional Voices (voice) (uncredited) |
| WWendell KinneyCruise Guest (uncredited) | Cruise Guest (uncredited) |
