 Justin LongHumphrey (voice) | Humphrey (voice) |
 Hayden PanettiereKate (voice) | Kate (voice) |
 Dennis HopperTony (voice) | Tony (voice) |
 Danny GloverWinston (voice) | Winston (voice) |
 Larry MillerMarcel (voice) | Marcel (voice) |
 Eric PricePaddy / Mooch (voice) | Paddy / Mooch (voice) |
 Vicki LewisEve (voice) | Eve (voice) |
 Chris CarmackGarth (voice) | Garth (voice) |
 Kevin SussmanShakey (voice) | Shakey (voice) |
 Brian DonovanSalty (voice) | Salty (voice) |
 Christina RicciLilly (voice) | Lilly (voice) |
 Elizabeth TullochSweets (voice) | Sweets (voice) |
 Christine LakinReba (voice) | Reba (voice) |
 Mindy SterlingDebbie (voice) | Debbie (voice) |
 Fred TatascioreGarn (voice) | Garn (voice) |
 Nika FuttermanPorcupine (voice) | Porcupine (voice) |
 Mela LeeCandy (voice) | Candy (voice) |
 Steve VinovichPark Ranger (voice) | Park Ranger (voice) |
 Aziz AnsariThug (voice) (uncredited) | Thug (voice) (uncredited) |
 Eric LopezCan-do (voice) | Can-do (voice) |
 Marilyn TokudaClaws / Janice (voice) | Claws / Janice (voice) |
| MMaya KayBear Cub (voice) (as Maya Feltheimer) | Bear Cub (voice) (as Maya Feltheimer) |
 Toby HussTruck Stop Employee (voice) | Truck Stop Employee (voice) |
