Three Nuyorican sisters navigate the daunting life challenges of single motherhood, career, and family, all while finding humor and solace within the bond of sisterhood.
| Actor | Role |
|---|---|
 Elizabeth RodriguezDaisy | Daisy |
 Liza Colón-ZayasIda | Ida |
 Daphne Rubin-VegaSerene | Serene |
 Max CasellaTim | Tim |
 Bobby CannavaleGabe | Gabe |
 Felix SolisDesmond | Desmond |
 Michael RispoliRay | Ray |
 Shyrley RodriguezConnie | Connie |
 Mackenzie LansingNina | Nina |
 J. Cameron BarnettClint | Clint |
 Quincy Tyler BernstineSandra | Sandra |