James Herriot is a vet in Yorkshire, England, during the 1930s. He is assigned to the practice of Siegfried Farnon, who—together with his mischievous brother Tristan—already have a successful business. James undergoes a variety of adventures during his work, which are just as often caused by the characters of the county, including the Farnon brothers, as the animals in his care.
| Actor | Role |
|---|---|
 Simon WardJames Herriot | James Herriot |
 Anthony HopkinsSiegfried Farnon | Siegfried Farnon |
 Lisa HarrowHelen Alderson | Helen Alderson |
| BBrian StirnerTristan Farnon | Tristan Farnon |
 Freddie JonesCranford | Cranford |
 T. P. McKennaSoames | Soames |
 Brenda BruceMiss Harbottle | Miss Harbottle |
 John CollinMr Alderson | Mr Alderson |
| CChristine BuckleyMrs Hall | Mrs Hall |
| JJane CollinsConnie | Connie |
 Fred FeastFarmer in Cinema | Farmer in Cinema |
| GGlynne GeldartJoyce | Joyce |
 Harold GoodwinDinsdale's Uncle | Dinsdale's Uncle |
 Doreen MantleMrs Seaton | Mrs Seaton |
 John NettletonHead Waiter | Head Waiter |
 Daphne OxenfordMrs. Pumphrey | Mrs. Pumphrey |
 Bert PalmerMr. Dean | Mr. Dean |
| JJohn ReesGeoff Mallock | Geoff Mallock |
 Jenny RunacrePamela | Pamela |
| JJane SoloBrenda | Brenda |