When Alita awakens with no memory of who she is in a future world she does not recognize, she is taken in by Ido, a compassionate doctor who realizes that somewhere in this abandoned cyborg shell is the heart and soul of a young woman with an extraordinary past.
| Actor | Role |
|---|---|
 Rosa SalazarAlita | Alita |
 Christoph WaltzDr. Dyson Ido | Dr. Dyson Ido |
 Jennifer ConnellyChiren | Chiren |
 Mahershala AliVector | Vector |
 Ed SkreinZapan | Zapan |
 Jackie Earle HaleyGrewishka | Grewishka |
 Keean JohnsonHugo | Hugo |
 Lana CondorKoyomi | Koyomi |
 Jorge Lendeborg Jr.Tanji | Tanji |
 Eiza GonzálezNyssiana | Nyssiana |
 Jeff FaheyMcTeague | McTeague |
 Idara VictorNurse Gerhad | Nurse Gerhad |
 Rick YuneMaster Clive Lee | Master Clive Lee |
 Derek MearsRomo | Romo |
 Leonard WuKinuba | Kinuba |
 Racer RodriguezClaymore | Claymore |
 Marko ZarorAjakutty | Ajakutty |
| HHugo PerezJacked Cyborg | Jacked Cyborg |
 Casper Van DienAmok | Amok |
 Billy BlairZapan's Cronie #1 | Zapan's Cronie #1 |
 Jamie LandauZapan's Cronie #2 | Zapan's Cronie #2 |
 Dimitrius PulidoCyborg Jacking Victim | Cyborg Jacking Victim |
 Patrick GathronAntioch | Antioch |
 Elle LaMontScrewhead | Screwhead |
 Alex LivinalliBlue Wingman | Blue Wingman |
 Neal KodinskyRed Wingman | Red Wingman |
| AAnthony BandmannMace | Mace |
 Alan TrongKumaza | Kumaza |
 Sam MedinaStinger | Stinger |
| TTod JunkerExploder | Exploder |