Journey through the human experience as the pandemic tests what we are made of both as individuals and as a culture.
| Actor | Role |
|---|---|
 Mitchell HoogNarrator | Narrator |
 Krista AllenDiane (Quarentales Segment) | Diane (Quarentales Segment) |
 Eric RobertsRussell (Quarantales Segment) | Russell (Quarantales Segment) |
 Eliza RobertsDebbie (Quarantales Segment) | Debbie (Quarantales Segment) |
 Robert PicardoDr. Robinson (Past Cure Segment) | Dr. Robinson (Past Cure Segment) |
 Tionne WatkinsCheryl | Cheryl |
 Debra WilsonPam (Quarantales Segment) | Pam (Quarantales Segment) |
 Michael WelchAllen (Quarantales Segment) | Allen (Quarantales Segment) |
 Frances Lee McCain'Bubbie' Lieberman (Ushering the Light) | 'Bubbie' Lieberman (Ushering the Light) |
| AAmber Lynn AshleyAlisha (Quarantales Segment) | Alisha (Quarantales Segment) |
 Jason PotterAndy (Quarantales Segment) | Andy (Quarantales Segment) |
 Ted MaritzRexton (Quarantales Segment) | Rexton (Quarantales Segment) |
| BBrian McCulleyTrenton Wells (Quarantales Segment) | Trenton Wells (Quarantales Segment) |
| JJohn CrockettNeighbor (Quarantales Segment) | Neighbor (Quarantales Segment) |
 Pari RoehiAbby | Abby |