The lives of three lonely strangers intersect while commuting on New York's 1 and 9 subway lines.
| Actor | Role |
|---|---|
 Heather GrahamRose Phipps | Rose Phipps |
 Victor RasukSimon Colon | Simon Colon |
 Dominic ChianeseTommaso Pensara | Tommaso Pensara |
| EErika MichelsClaire | Claire |
 Marlene ForteMarta Colon | Marta Colon |
 Richard PetrocelliMr. Sneider | Mr. Sneider |
 Karina ArroyaveChristina | Christina |
| AAdriana BremontBecca | Becca |
| NNicolle RochelleMelanie | Melanie |
 Felix SolisRolando | Rolando |
 Anthony CirilloCarlitos | Carlitos |
 Karen OlivoAna | Ana |
 Alexis SmithYvette | Yvette |
 Jamie TirelliAd Agency Worker | Ad Agency Worker |
 Elizabeth PeñaIsabel Parades | Isabel Parades |
 William BaldwinMark Phipps | Mark Phipps |
| LLiam de VillaCasey | Casey |
| KKeren Love PerilmanJen | Jen |
| DDamian PorterDrew | Drew |
| FFrank PicarazziSubway Musician | Subway Musician |
| NNicole KohnenKaren (Clinic Receptionist) | Karen (Clinic Receptionist) |
| MMarti VendettiClinic Receptionist Two | Clinic Receptionist Two |
| TTony ChiroldesPatient | Patient |
 Teddy ColucaJimmy | Jimmy |