Two young brothers are separated when their wagon train is attacked and their parents killed. One brother Cherokee is raised by Indians and the other, the Kansas Kid, by the outlaw gang leader Buff. Twenty years later they unknowingly meet again when the Kid goes after wagons being guided by Cherokee.
| Actor | Role |
|---|---|
 Jack RandallCherokee | Cherokee |
 Frank YaconelliLopez | Lopez |
 Joyce BryantMary Masters | Mary Masters |
 Hal PriceBuckskin | Buckskin |
 Dennis MooreJimmy Winters, aka The Kansas Kid | Jimmy Winters, aka The Kansas Kid |
 Glenn StrangeJeff Masters | Jeff Masters |
| BBob CardBuff Gordon | Buff Gordon |
 Bud OsborneHenchman Lex | Henchman Lex |
 Monte RawlinsHenchman Rip | Henchman Rip |
| WWylie GrantHenchman Rawhide | Henchman Rawhide |
 Iron Eyes CodyBrave | Brave |
| BBuddy CoxYoung Jimmy | Young Jimmy |
| TTexi-Ray CoxYoung Jack | Young Jack |