 Keanu ReevesBob Arctor | Bob Arctor |
 Robert Downey Jr.James Barris | James Barris |
 Woody HarrelsonErnie Luckman | Ernie Luckman |
 Winona RyderDonna Hawthorne | Donna Hawthorne |
 Rory CochraneCharles Freck | Charles Freck |
 Mitch BakerBrown Bear Lodge Host | Brown Bear Lodge Host |
| SSean AllenAdditional Fred Scramble Suit Voice (voice) | Additional Fred Scramble Suit Voice (voice) |
| CCliff HabyVoice from Headquarters (voice) | Voice from Headquarters (voice) |
 Steven Chester PrinceCop | Cop |
| NNatasha ValdezWaitress | Waitress |
| MMark TurnerAdditional Hank Scramble Suit Voice (voice) | Additional Hank Scramble Suit Voice (voice) |
 Chamblee FergusonMedical Deputy #2 | Medical Deputy #2 |
 Angela RawnaMedical Deputy #1 | Medical Deputy #1 |
| EEliza StevensArctor's Daughter #1 | Arctor's Daughter #1 |
| SSarah MenchacaArctor's Daughter #2 | Arctor's Daughter #2 |
 Melody ChaseArctor's Wife | Arctor's Wife |
| LLeif AndersFreck Suicide Narrator (voice) | Freck Suicide Narrator (voice) |
 Turk PipkinCreature | Creature |
 Alex E. JonesStreet Prophet | Street Prophet |
 Lisa Marie NewmyerConnie | Connie |
 Wilbur PennMedical Officer #1 | Medical Officer #1 |
 Ken WebsterMedical Officer #2 | Medical Officer #2 |
| HHugo PerezNew Path Staff Member #1 | New Path Staff Member #1 |
 Rommel SulitNew Path Staff Member #2 | New Path Staff Member #2 |
 Dameon ClarkeMike | Mike |
 Ryan MeltonNew Path Resident #1 | New Path Resident #1 |
| LLeila PlummerNew Path Resident #2 | New Path Resident #2 |
 Jason DouglasNew Path Farm Manager | New Path Farm Manager |
 Marco PerellaDonald | Donald |
 Joe BasquezUndercover Cop (uncredited) | Undercover Cop (uncredited) |
