 E. G. DailyTommy Pickles (voice) | Tommy Pickles (voice) |
 Christine CavanaughChuckie Finster (voice) | Chuckie Finster (voice) |
 Kath SouciePhil DeVille / Lil DeVille / Betty DeVille (voice) | Phil DeVille / Lil DeVille / Betty DeVille (voice) |
 Cree SummerSusie Carmichael / Edwin Carmichael (voice) | Susie Carmichael / Edwin Carmichael (voice) |
 Dionne QuanKimi Finster (voice) | Kimi Finster (voice) |
 Ron GlassRandy Carmichael (voice) | Randy Carmichael (voice) |
 Irma P. HallAunt T. (voice) | Aunt T. (voice) |
 Crystal ScalesBuster Carmichael (voice) | Buster Carmichael (voice) |
 Hattie WinstonLucy Carmichael / Lucy's Mom (voice) | Lucy Carmichael / Lucy's Mom (voice) |
 Kimberly BrooksYoung Lucy (voice) | Young Lucy (voice) |
 Bill CobbsUncle Charles (voice) | Uncle Charles (voice) |
| EErv ImmemanRadio Announcer (voice) | Radio Announcer (voice) |
 Kevin Michael RichardsonMartin Luther King Jr. (voice) | Martin Luther King Jr. (voice) |
| CCynthia Kaye HuntChoir Soloist (voice) | Choir Soloist (voice) |
 Joe AlaskeyGrandpa Lou Pickles (voice) | Grandpa Lou Pickles (voice) |
 Sam SalettaAdditional Voices (voice) | Additional Voices (voice) |
 Bettina BushAlisa Carmichael (voice) | Alisa Carmichael (voice) |