 Anne ShirleyJean Johnson | Jean Johnson |
 Edward EllisDr. John Abbott | Dr. John Abbott |
 Lee BowmanDick Abbott | Dick Abbott |
 William HenryHoward Sykes | Howard Sykes |
 John WrayTom Johnson | Tom Johnson |
 Granville BatesGeorge Sykes | George Sykes |
 Harlan BriggsHomer Ramsey | Homer Ramsey |
 Frank M. ThomasJode Harkness | Jode Harkness |
 Dickie JonesDick Abbott (as a boy) | Dick Abbott (as a boy) |
 Dick ElliottHank | Hank |
| CCarole LeeteJean Johnson - Age 4 | Jean Johnson - Age 4 |
 Gilbert EmeryDr. Robinson | Dr. Robinson |
 Joe De StefaniJorgensen | Jorgensen |
 Barlowe BorlandDoctor with News of Polio Outbreak (uncredited) | Doctor with News of Polio Outbreak (uncredited) |
 Maurice CostelloTown Councilor (uncredited) | Town Councilor (uncredited) |
 Sarah EdwardsClerk (uncredited) | Clerk (uncredited) |
 Byron FoulgerBank Teller (uncredited) | Bank Teller (uncredited) |
 Bud GearyWorried Father (uncredited) | Worried Father (uncredited) |
 Julia GriffithFuneral Observer (uncredited) | Funeral Observer (uncredited) |
 Charles HaltonAtty. Clyde Perkins (uncredited) | Atty. Clyde Perkins (uncredited) |
 Vinton HayworthHuber (uncredited) | Huber (uncredited) |
 John InceMan at Hospital Dedication (uncredited) | Man at Hospital Dedication (uncredited) |
 Lloyd IngrahamFuneral Observer (uncredited) | Funeral Observer (uncredited) |
| FFrank JaquetFuneral Observer (uncredited) | Funeral Observer (uncredited) |
 Wilfred LucasMan at Hospital Dedication (uncredited) | Man at Hospital Dedication (uncredited) |
| EEdmund MortimerMedical Association Board Member (uncredited) | Medical Association Board Member (uncredited) |
 Frank O'ConnorMan at Hospital Dedication (uncredited) | Man at Hospital Dedication (uncredited) |
| SSam RiceFuneral Observer (uncredited) | Funeral Observer (uncredited) |
 Larry SteersMedical Association Board Member (uncredited) | Medical Association Board Member (uncredited) |
 Grady SuttonRaymond (uncredited) | Raymond (uncredited) |
