After exorcising the demons of his ex, Malcolm starts afresh with his new girlfriend and her two children. After moving into their dream home, Malcolm is once again plagued by bizarre paranormal events.
| Actor | Role |
|---|---|
 Marlon WayansMalcolm | Malcolm |
 Jaime PresslyMegan | Megan |
 Essence AtkinsKisha | Kisha |
 Gabriel IglesiasMiguel | Miguel |
 Missi PyleNoreen | Noreen |
 Ashley RickardsBecky | Becky |
 Affion CrockettRay Ray | Ray Ray |
 Steele StebbinsWyatt | Wyatt |
 Rick OvertonProfessor Wilde | Professor Wilde |
 Hayes MacArthurNed | Ned |
 Dave SheridanAgouhl | Agouhl |
 Cedric the EntertainerFather Williams | Father Williams |
 Kurt CarleyDr. Rousch | Dr. Rousch |
 Tom VirtueFather Callahan | Father Callahan |
 Kym WhitleyChurch Lady | Church Lady |
 Gregg WayansPolice Officer | Police Officer |
| MMikal KartvedtPolice Officer | Police Officer |
 Mark HenryTough Voice Guy | Tough Voice Guy |
 Iva La'Shawn1st Grade Teacher | 1st Grade Teacher |
 Taylor John SmithJoey | Joey |
 Sophie DeeHot Coed | Hot Coed |
 Mari PossaHot Coed | Hot Coed |
| AAudrey PetenbrinkPool Daughter (uncredited) | Pool Daughter (uncredited) |
 Scott BurnKill Family Dad (uncredited) | Kill Family Dad (uncredited) |
 Chris GannPool Dad (uncredited) | Pool Dad (uncredited) |
 Melissa BarkerPool Mom (uncredited) | Pool Mom (uncredited) |