Garry Trudeau's classic characters (Mike Doonesbury, Zonker, etc.) examine how their lifestyles, priorities, and concerns have changed since the end of their idealistic college days in the 1960s. Preserved by the Academy Film Archive in 2012.
| Actor | Role |
|---|---|
 James Allen BrewerJimmy Thudpucker | Jimmy Thudpucker |
 Barbara HarrisJoanie Caucus | Joanie Caucus |
 Charles LevinMark Slackmeyer | Mark Slackmeyer |
| RRebecca NelsonBarbara Ann 'Boopsie' Boopstein | Barbara Ann 'Boopsie' Boopstein |
| WWilliam Sloane CoffinThe Reverend Scott Sloan | The Reverend Scott Sloan |
 Jack GilfordReferee | Referee |
| MMichelle BrowneJeannie | Jeannie |
| RRichard CoxZonker Harris (voice) | Zonker Harris (voice) |
| DDavid GrantMike Doonesbury (voice) | Mike Doonesbury (voice) |
| RRichard BrunoB.D. (voice) | B.D. (voice) |
| MMark BakerKirby (voice) | Kirby (voice) |
| RRick EliceFrank (voice) (as Eric Elice) | Frank (voice) (as Eric Elice) |
 Will JordanSportscaster (voice) | Sportscaster (voice) |
| LLinda BaerEllie (voice) | Ellie (voice) |
| EEric JaffeHowie (voice) | Howie (voice) |
| TThomas BaxtonRufus (voice) | Rufus (voice) |
| LLenny JacksonMagus (voice) | Magus (voice) |
| PPatrice LeftwichVirgin Mary (voice) | Virgin Mary (voice) |
| BBen Haley Jr.Calvin (voice) | Calvin (voice) |