Tom, greeting-card writer and hopeless romantic, is caught completely off-guard when his girlfriend, Summer, suddenly dumps him. He reflects on their 500 days together to try to figure out where their love affair went sour, and in doing so, Tom rediscovers his true passions in life.
| Actor | Role |
|---|---|
 Joseph Gordon-LevittTom | Tom |
 Zooey DeschanelSummer | Summer |
 Geoffrey ArendMcKenzie | McKenzie |
 Chloë Grace MoretzRachel | Rachel |
 Matthew Gray GublerPaul | Paul |
 Clark GreggVance | Vance |
 Patricia BelcherMillie | Millie |
 Rachel BostonAlison | Alison |
 Minka KellyAutumn | Autumn |
| CCharles WalkerMillie's New Husband | Millie's New Husband |
 Ian Reed KeslerDouche | Douche |
 Darryl Alan ReedBus Driver | Bus Driver |
 Valente RodriguezEmployee #1 | Employee #1 |
 Yvette Nicole BrownNew Secretary | New Secretary |
 Nicole ViciusPartygoer | Partygoer |
| NNatalie BorenAnother Partygoer | Another Partygoer |
 Maile FlanaganRhoda | Rhoda |
 Darryl SivadUsher | Usher |
 Gregory A. ThompsonMinister | Minister |
| MMichael BodieMan | Man |
| JJohn MackieMime | Mime |
| JJacob StroopCupid | Cupid |
| KKevin MichaelWedding Singer | Wedding Singer |
| SSid WilnerGrossman | Grossman |
 Richard McGonagleNarrator (voice) | Narrator (voice) |
 Jean-Paul VignonFrench Narrator (voice) | French Narrator (voice) |
 Bryan AnthonyDancer | Dancer |
| SSybil AzurDancer | Dancer |
 Cheryl BaxterDancer | Dancer |
 Gustavo CarrDancer | Dancer |