 Willem DafoeCisco | Cisco |
 Shanyn LeighSkye | Skye |
| TToni RedmanMan on phone (voice) | Man on phone (voice) |
 Pat KiernanNews Anchor | News Anchor |
| FFrancis KuipersTeddy | Teddy |
| SSelena MarsSkype Dancer | Skype Dancer |
| JJustin RestivoSuicide | Suicide |
| BBojana VasikWoman with coat | Woman with coat |
| TTrung NguyenDelivery Boy | Delivery Boy |
| TTriana JacksonCisco's Daughter | Cisco's Daughter |
| DDierdra McDowellCisco's Ex | Cisco's Ex |
 Natasha LyonneTina | Tina |
 Anita PallenbergSky's Mother | Sky's Mother |
 Paul HippNoah | Noah |
 José SolanoDrug Dealer | Drug Dealer |
| JJudith SalazarFriend of Dealer | Friend of Dealer |
 Paz de la HuertaWoman on Street | Woman on Street |
 Frank AquilinoMan Outside Bar | Man Outside Bar |
| MMaria Grazia SchirripaWailing Woman | Wailing Woman |
| MMuriel Sprissler DafoeCisco's Mother | Cisco's Mother |
| NNicholas DeceoliaMan in Window | Man in Window |
 Tenzin GyatsoSelf (archive footage) (uncredited) | Self (archive footage) (uncredited) |
 Al GoreSelf (archive footage) (uncredited) | Self (archive footage) (uncredited) |
| AAnthony PerulloContrition (uncredited) | Contrition (uncredited) |
 Charlie RoseSelf (archive footage) (uncredited) | Self (archive footage) (uncredited) |
| TTyler StoneMan in Heels (uncredited) | Man in Heels (uncredited) |
| TThomas Michael SullivanPriest (uncredited) | Priest (uncredited) |
| NNicola TranquillinoNewscaster (uncredited) | Newscaster (uncredited) |
