Tucker and Hamid are going to be grandfathers for the first time, but only if they can come together long enough to save their first-born grandchild.
| Actor | Role |
|---|---|
 Denise RichardsChristine | Christine |
 Val KilmerBiden | Biden |
 Taylor ColeKate | Kate |
 Dominique SwainIngrid | Ingrid |
 William BaldwinSaul | Saul |
 Robert KnepperJoe | Joe |
 Tom BerengerTucker Jefferson | Tucker Jefferson |
 Greg GrunbergDr. Cooper | Dr. Cooper |
 Ken DavitianCharles | Charles |
 Michael SirowDr. Friedman | Dr. Friedman |
| DDoug HaleyJoshua | Joshua |
| JJoel MichaelyMoyel / Rabbi | Moyel / Rabbi |
| JJay AbdoHamid | Hamid |
 Reza Sixo SafaiBen | Ben |
| CCarrie Jo CrosbySurgeon | Surgeon |
 Soo Yeon LeeJin-Ho | Jin-Ho |
 Kristina KorsholmSophie | Sophie |
 Mitchell L. JohnsonOfficer Kahiapo | Officer Kahiapo |
 Vincent van HinteReporter Vinnie | Reporter Vinnie |
| SSean McElweeJustin | Justin |
| TTarek ZohdyHector | Hector |
| TTomer AlmagorGuest | Guest |
| AAlina SmolyarHannah | Hannah |
 Nina NayebiGowhar | Gowhar |
 Nathalie BiermannsSabrina | Sabrina |
| HHeather ComptonYoung Nurse | Young Nurse |
| JJames LipsiusCamera Man | Camera Man |
| DDavid GolshanDirector of TV station | Director of TV station |
 Kian KavousiD. Mac Arthur | D. Mac Arthur |
| AAnthony RyanUniversity Student | University Student |