The second sequel to 2009's Indestructible sees the story picking up one year after the events in 2018's Indestructible: Afterlife.
| Actor | Role |
|---|---|
| LLauren LasseigneStephanie Kersey | Stephanie Kersey |
 Matt SpeaseJames Kirby | James Kirby |
| EEmmi MullenRachel Tripp | Rachel Tripp |
| SSusan MeekMegan Tripp | Megan Tripp |
 Jeff AllenDoug Tripp | Doug Tripp |
| JJade Michael LaFontRobert Kersey | Robert Kersey |
| VV. Duwane LedbetterMayor Pat Tucker | Mayor Pat Tucker |
| BBrian HardinDoctor Nathan Gage | Doctor Nathan Gage |