| JJessica StrausThe Amazon (voice) | The Amazon (voice) |
 Michael McConnohieThe Necromancer (voice) | The Necromancer (voice) |
| DDavid ThomasThe Barbarian (voice) | The Barbarian (voice) |
| LLiana YoungThe Sorceress (voice) | The Sorceress (voice) |
 Larry B. ScottThe Paladin (voice) | The Paladin (voice) |
| MMichael BellThe Druid / Nihlathak (voice) | The Druid / Nihlathak (voice) |
| CCarrie GordonThe Assassin / Natalya (voice) | The Assassin / Natalya (voice) |
| RRahul KholiThe Warlock (voice) | The Warlock (voice) |
| MMichael GoughDeckard Cain (voice) | Deckard Cain (voice) |
| FFrank GorshinMarius / Lysander (voice) | Marius / Lysander (voice) |
| EEd TrottaTyrael / Izual / The Ancient (voice) | Tyrael / Izual / The Ancient (voice) |
| JJames HarperThe Dark Wanderer / Tal Rasha / Griez (voice) | The Dark Wanderer / Tal Rasha / Griez (voice) |
| BBill RoperDiablo / Hadriel (voice) | Diablo / Hadriel (voice) |
| MMilton JamesBaal (voice) | Baal (voice) |
| PPaul EidingMephisto / Narrator (voice) | Mephisto / Narrator (voice) |
| LLani MinellaAndariel / Blood Raven / The Countess / Malah / The Ancient (voice) | Andariel / Blood Raven / The Countess / Malah / The Ancient (voice) |
| EEve BrentAkara (voice) | Akara (voice) |
| GGlynnis Talken-CampbellKashya (voice) | Kashya (voice) |
| TTiffany HayesCharsi (voice) | Charsi (voice) |
| BBrian GeorgeGheed / Drognan / Alkor (voice) | Gheed / Drognan / Alkor (voice) |
| NNina MintonFlavie (voice) | Flavie (voice) |
 Roz WittAtma (voice) | Atma (voice) |
 Tony PopeElzix (voice) | Elzix (voice) |
| MMartitia PalmerFara (voice) | Fara (voice) |
| JJim KilleenJerhyn (voice) | Jerhyn (voice) |
| DDeem BristowMeshif (voice) | Meshif (voice) |
 Castulo GuerraGeglash (voice) | Geglash (voice) |
| JJennifer SmitheeAsheara (voice) | Asheara (voice) |
| BBernie WilkinsHratli (voice) | Hratli (voice) |
| WWilliam H. BassettOrmus (voice) | Ormus (voice) |