Womanizer and airline pilot Jack Gordon must fly the world's fastest airliner from New York to California while dealing with dangerous jewel thieves on the run from the law.
| Actor | Role |
|---|---|
 Fred MacMurrayJack Gordon | Jack Gordon |
 Joan BennettFelice Rollins | Felice Rollins |
 Zasu PittsMiss Harkins | Miss Harkins |
 John HowardFreddie Scott | Freddie Scott |
 Benny BartlettWaldemar Pitt III | Waldemar Pitt III |
 Grace BradleyTrixie La Brey | Trixie La Brey |
 Alan BaxterCurtis Palmer | Curtis Palmer |
 Brian DonlevyJames Evarts | James Evarts |
 Ruth DonnellyVi Johnson | Vi Johnson |
 Fred KeatingGregore Stephani | Gregore Stephani |
 Adrienne MardenAnn McKenna | Ann McKenna |
 Dean JaggerHap Waller | Hap Waller |
| MMildred StoneRuth Bradford | Ruth Bradford |
 Jack MulhallHorace Lander | Horace Lander |
| CClyde DilsonFat Richhauser | Fat Richhauser |
 Dennis O'KeefeBaker-Co-Pilot | Baker-Co-Pilot |
 Granville BatesPop Andrews | Pop Andrews |
 Marie PrevostWaitress in Omaha | Waitress in Omaha |
| BBruce WarrenTex Doyle | Tex Doyle |
| CCahit IrgatDidrikson | Didrikson |
 Hayri EsenNot listed | Not listed |