Based on a real-life incident, 100 Degree Celsius revolves around the lives of five women - a housewife, banker, IT professional, TV reporter and a college student.
| Actor | Role |
|---|---|
 Shweta MenonNila | Nila |
 BhamaNancy | Nancy |
 Meghana RajRevathy | Revathy |
 AnanyaGanga | Ganga |
| HHaritha ParokodLovely | Lovely |
 ArunNot listed | Not listed |
 Mithun RameshHarithas Husband | Harithas Husband |
 Anjali P NairNanda | Nanda |