A group of friends reunite ten years after their high-school graduation.
| Actor | Role |
|---|---|
 Channing TatumJake | Jake |
 Jenna DewanJess | Jess |
 Justin LongMarty | Marty |
 Max MinghellaAJ | AJ |
 Oscar IsaacReeves | Reeves |
 Chris PrattCully | Cully |
 Ari GraynorSam | Sam |
 Scott PorterScott | Scott |
 Eiko NijoSuki | Suki |
 Aubrey PlazaOlivia | Olivia |
 Rosario DawsonMary | Mary |
 Ron LivingstonPaul | Paul |
 Anthony MackieAndre | Andre |
 Kate MaraElise | Elise |
 Kelly NoonanJulie | Julie |
 Brian GeraghtyGarrity | Garrity |
 Nick ZanoNick Vanillo | Nick Vanillo |
 Isaac KappyGutterball | Gutterball |
 Aaron YooPeter Jung | Peter Jung |
 Lynn CollinsAnna | Anna |
 Sara A. EmamiSara | Sara |
 Mike MillerBartender | Bartender |
 Bryce HayesPushy Classmate | Pushy Classmate |
| MMarie A.K. McMasterPushy Classmate's Wife | Pushy Classmate's Wife |
| BBrady KephartHair Gel Guy | Hair Gel Guy |
| KKenneth McGlothinTaller Geek | Taller Geek |
| TTodd MaltaTodd, the Husband | Todd, the Husband |
 Lauren PooleTodd's Wife | Todd's Wife |
| CCatherine StoneCat | Cat |
 Alex KnightBand Geek | Band Geek |